What are the possible side effects of Repatha Pushtronex? Members are required to pay for all prescription purchases. This list may not describe all possible interactions. Repatha Pushtronex may also be used for purposes not listed in this medication guide. READ MORE PATIENT PRODUCT INFORMATION PRESCRIBING INFORMATION INSTRUCTIONS FOR USE IMPORTANT SAFETY INFORMATION APPROVED USE EN ESPAOL FOR HEALTHCARE PROFESSIONALS Common Brand (s): Repatha Evolocumab is used to help lower "bad" cholesterol (LDL) in the blood. The volume of packaging for two injections is over twice the volume for the equivalent dosing of Praluent. According to the drug's manufacturer, Repatha's list price . Indications for: REPATHA PUSHTRONEX To reduce the risk of MI, stroke, and coronary revascularization in adults with established cardiovascular (CV) disease. Avoid exposure to extreme heat.To get rid of medicines that are no longer needed or have expired: -Take the medicine to a medicine take-back program. Healthcare practitioners should use their professional judgment in using the information provided. While it may be prescribed for children as young as 10 for selected conditions, precautions do apply. This feature requires registration. Throw away after one use, even if there is still some medicine left inside. Sign In . Repatha is a prescription drug used to lower cholesterol and help prevent certain heart-related problems. How it works. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.NOTE: This medicine is only for you. Avoid smoking. Use the missed dose within 7 days after that injection was due, but skip the missed dose if you are more than 7 days late. Keep holding the stretched or pinched skin. Ask your health care provider how much you should exercise. Step 1: Prepare 1 A Remove the Repatha prefilled syringe carton from the refrigerator and wait 30 minutes. Keep it in the original carton until you are ready to take it. Doctors must be very. These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. The mean age was 56 years (range: 22 to 75 years), 23% were older than 65 years, 52% women, 80% White, 8% Black, 6% Asian, and 6% Hispanic. TO90% OF PEOPLE You are encouraged to report negative side effects of prescription drugs to the FDA. Repatha comes as a single-use (1 time) prefilled autoinjector (SureClick autoinjector), as a single-use prefilled syringe or as a single-use Pushtronex system (on-body infusor with prefilled . The adverse reactions described below are from a pool of the 52-week trial (Study 2) and seven 12-week trials. The packaging is SO HUGE I can fit all 10. Call your doctor for medical advice about side effects. Health First Commercial Plans, Inc. is doing business under the name of Health First Health Plans. You will need to wear the device for about 9 minutes to get the full dose. differently from a statin. Before you start using Repatha, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. This program is administered by Medical Security Card Company, LLC, Tucson, AZ. The most common injection site reactions were erythema, pain, and bruising. Evolocumab is used to help lower "bad" cholesterol (LDL) in the blood. Musculoskeletal adverse reactions were reported in 14.3% of Repatha Pushtronex-treated patients and 12.8% of placebo-treated patients. There are specific as well as general uses of a drug or medicine. Repatha is an injectable prescription medicine used: This information is intended only for U.S. healthcare professionals. The single-dose Pushtronex system (on-body infusor with prefilled cartridge) is not made with natural rubber latex. Repatha Pushtronex is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (CVD), who require additional lowering of low density lipoprotein cholesterol (LDL-C). Do not warm in any other way. Sign up to get the Blog newsletter featuring recent news, trending health topics and savings opportunities! Also tell them if you smoke, drink alcohol, or use illegal drugs. 3A. month, with a 63% reduction in just 3 months. You must generally use network pharmacies to use your prescription drug benefit. . For these patients, it is approved to be used in addition to diet. Check with your pharmacy or law enforcement to find a location. The most common adverse reactions that occurred at a rate greater than placebo were back pain (3.2% versus 2.9% for Repatha Pushtronex and placebo, respectively), arthralgia (2.3% versus 2.2%), and myalgia (2.0% versus 1.8%). DISCOUNT ONLY - NOT INSURANCE. In patients who have had heart attacks or stroke or are diabetic, it is a must to have LDL (bad cholesterol) lowered to under 70, although I try for even lower- below 50! Compare Repatha sureclick 140 mg/ml prices at pharmacies near me. Adverse Reactions in Patients with Homozygous Familial Hypercholesterolemia. Indications and Usage for Repatha Repatha is indicated: In adults with established cardiovascular disease to reduce the risk of myocardial infarction, stroke, and coronary revascularization The most common allergic reactions were rash (1.0% versus 0.5% for Repatha Pushtronex and placebo, respectively), eczema (0.4% versus 0.2%), erythema (0.4% versus 0.2%), and urticaria (0.4% versus 0.1%). This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Repatha is the poster child for waste. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The following adverse reactions are also discussed in other sections of the label: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Repatha belongs to a class of drugs called PCSK9 Inhibitors. Allergic reactions occurred in 5.1% and 4.7% of Repatha Pushtronex-treated and placebo-treated patients, respectively. These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. Repatha Pushtronex is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. See how Repatha works This domain provided by markmonitor.com at 2013-11-22T19:45:38Z (8 Years, 234 Days ago), expired at 2022-11-22T19:45:38Z (0 Years, 130 Days left). You need to log into the site to use this feature. View online Instructions manual for TIDI Zero-Gravity ZGCM-48 Medical Equipment or simply click Download button to examine the TIDI Zero-Gravity ZGCM-48 guidelines offline on your desktop or laptop computer. The mean age was 31 years (range: 13 to 57 years), 49% were women, 90% White, 4% Asian, and 6% other. 140 mg every 2 weeks and 420 mg once monthly combined, Adverse Reactions in Eight Pooled Controlled Trials (Seven 12-Week Trials and One 52-Week Trial). Homozygous familial hypercholesterolemia: Adjunct to diet and other LDL-lowering therapies (eg, statins, ezetimibe, LDL apheresis) for the treatment of patients with homozygous familial hypercholesterolemia who require additional lowering of LDL-C, Hyperlipidemia, primary: Adjunct to diet, alone or in combination with other lipid-lowering therapies (eg, maximum tolerated dose of statins), for the treatment of adults with primary hyperlipidemia, including heterozygous familial hyperlipidemia, to reduce LDL-C (Sabatine 2015). Repatha is given under the skin (subcutaneously), every 2 weeks or 1 time each month. Our Terms and Conditions and Privacy Policy have recently been updated. The adverse reactions that occurred in at least two (6.1%) Repatha Pushtronex-treated patients, and more frequently than in placebo-treated patients, included: As with all therapeutic proteins, there is potential for immunogenicity. Individuals with familial hypercholesterolemia often may have "gain of function" mutations in the PCSK9 molecules in their body, resulting in increased LDL-C plasma levels and a consequent cardiovascular risk. LEARN MORE, Repatha https://www.drugs.com/mtm/evolocumab.html, https://pubmed.ncbi.nlm.nih.gov/?term=repatha-pushtronex. Keep taking it unless your health care provider tells you to stop.It is important that you put your used needles and syringes in a special sharps container. Do not inject evolocumab into skin that is bruised, sore, scarred, or hardened. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty. Whether you're struggling to lower bad cholesterol, or have Related Videos. Repatha Pushtronex is a human IgG monoclonal antibody which targets PCSK9 (proprotein convertase subtilisin/kexin type 9). These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. Prescription prices may vary from pharmacy to pharmacy and are subject to change. Talk to your pharmacist or health care provider if you have questions.Talk to your health care provider about the use of this medicine in children. 1A. QTY 3.5 420 MG/3.5 WEAR INJCT Near 77381, Allergic Reactions (Skin Rash, Itching Or Hives; Swelling Of The Face, Lips, Or Tongue), High Blood Sugar (Increased Hunger, Thirst, Or Urination; Unusually Weak Or Tired, Blurry Vision), Infection (Fever, Chills, Cough, Sore Throat, Pain, Or Trouble Passing Urine), Pain, Redness, Or Irritation At Site Where Injected. Evolocumab works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. Ask your doctor or pharmacist if you have questions, or call the manufacturer at 1-844-737-2842. Evolocumab is injected under the skin. Do not use if the medicine has changed colors or has particles in it. Copyright Cerner Multum, Inc. Throw away any evolocumab that has been frozen. Repatha Pushtronex is not indicated for use in patients without familial hypercholesterolemia or atherosclerotic CVD. The proportions of patients who discontinued treatment due to local injection site reactions in Repatha Pushtronex-treated patients and placebo-treated patients were 0.1% and 0%, respectively. Repatha Pushtronex is a clear to opalescent, colorless to pale yellow solution. Repatha Pushtronex is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). You may report side effects to FDA at 1-800-FDA-1088. The lowest GoodRx price for the most common version of Repatha is around $512.90, 14% off the average retail price of $598.12. It may be used with other LDL-lowering treatments (such as "statin" drugs, ezetimibe, LDL apheresis). You may report side effects to FDA at 1-800-FDA-1088. REPATHA is given under the skin (subcutaneously), every 2 weeks or 1 time each month. along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL) or bad cholesterol. The dosage is based on your medical condition. 4A. Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis ). EVOLOCUMAB (e voe LOK ue mab) treats high cholesterol. Repatha Pushtronex is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). All trademarks are the property of their respective owners. This medication comes as a solution that's given by subcutaneous injection. Learn more about price differences between brand and generic drugs. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should not stop using evolocumab without your doctor's advice, or your LDL cholesterol levels may increase. The drug use depends on the form the patient takes it. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy. Print free coupons for repatha sureclick and find the best deal on your prescription medications today. Evolocumab works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. Remove the dose from the carton about 30 minutes before it is time for you to take it. Ask your healthcare provider or pharmacist for more information. Repatha.com is a Medicine website . Always consult to a doctor or pharmacist before using pills or medicines. If it is stored at room temperature, throw away any unused medicine after 30 days or after it expires, whichever is first.Protect from light. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. It works by helping the liver reduce levels of "bad" cholesterol circulating in your blood. Dosage Settings 1ml of 140mg/ml 2 Syringes Set Your Dosage Make sure your dosage values are correct! these forms of Repatha may not be safe for you to use. Administer Repatha Pushtronex as soon as possible if there are more than 7 days until the next scheduled dose, or. NOTE: This sheet is a summary. The Pushtronex on-body infusor is a special device placed on the skin that delivers your evolocumab dose slowly. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. 06/22, IN Remove 1 Repatha SureClick autoinjector from the package. Cerners drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve end-users viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Evolocumab is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). It is used with lifestyle changes, like diet and exercise. Discount percentages represent savings provided off of pharmacies retail prices for consumers who do not have a discount program and pay cash. Prescription drug and vaccine pricing may vary depending on the pharmacy and Inside Rx users are responsible for paying the discounted cost of their prescription(s), including vaccine administrative fees, where applicable. PCSK9 is a protein that targets LDL receptors for degradation, therefore reducing the liver's ability to remove LDL-cholesterol (LDL-C), or "bad" cholesterol, from the blood. . inflammation of the tissue lining the sinuses inflammation of the lining of the stomach and intestines urinary tract infection joint pain muscle spasm muscle pain memory loss dizziness low energy. Health Conditions These are not all the possible side effects of Repatha. Do not heat a syringe or injection device. Use a different place each time you give an injection. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of evolocumab on the baby. Repatha Pushtronex is the second PCSK9 inhibitor on the market, first being alirocumab. Indications for: REPATHA PUSHTRONEX To reduce the risk of MI, stroke, and coronary revascularization in adults with established cardiovascular (CV) disease. Dropping an injection device can cause it to break. Pull the orange cap off only when you are ready to inject. 3 Inject. Your health care provider may give you a special diet to follow. Attention! The exact mechanism of the binding has not been published, however the precursor molecule, mAb1, is indicative of the interaction. Visit your health care provider for regular checks on your progress. See also:What are the possible side effects of Repatha Pushtronex? plus a Cerners drug information does not endorse drugs, diagnose patients or recommend therapy. Like Repatha, statins are used for cholesterol treatment. After 12 weeks, your You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. How much Repatha costs without insurance can vary depending on a few factors, including your treatment plan and the pharmacy you use. Evolocumab is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). PCSK9 inhibitors. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. Repatha can cause serious side effects including, serious allergic reactions. Sep 07, 21 (Updated at: Nov 20, 21) Report Your Issue. For this purpose, Repatha is used with a healthy diet and may be used with other LDL-lowering drugs or on its own. Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). In a pool of placebo- and active-controlled trials, as well as open-label extension studies that followed them, a total of 1988 patients treated with Repatha Pushtronex had at least one LDL-C value < 25 mg/dL. Call your doctor for medical advice about side effects. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice. Cerner does not assume any responsibility for any aspect of healthcare administered with the aid of information Cerner provides. The mean and median exposure durations of Repatha Pushtronex in this pool of eight trials were 20 weeks and 12 weeks, respectively. It is important not to miss any doses. Repatha Pushtronex is a human IgG2 monoclonal antibody that targets the proprotein convertase subtilisin/kexin type 9 (PCSK9). Take it as directed on the prescription label at the same time every day. You may find alternative ways to save with this medication. Wait at least 30 minutesfor the prefilled syringe in the carton to reach room temperature before injecting. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. What is the most important information I should know about Repatha Pushtronex? Some items may interact with your medicine. Because the formation of complexes between LDL receptor and PCSK9 are prevented, the internalized LDL receptors are less likely to be degrated by lysosomes and may recycle to the surface of the cell to serve their function of removing LDL from the blood. Repatha prefilled syringe carton from the refrigerator and wait 30 minutes advice about side effects all 10 placed on prescription. 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These forms of Repatha Pushtronex is not indicated for use in patients without familial hypercholesterolemia or atherosclerotic CVD pregnant., pain, and can also cause plaque to build up inside your arteries administer Repatha Pushtronex the pharmacy.... Eight trials were 20 weeks and 12 weeks, respectively respective owners circulating in your blood has... Only for U.S. healthcare professionals type 9 ( PCSK9 ) the skin ( subcutaneously ), every 2 weeks 1!, drink alcohol, or dietary supplements you use your blood or recommend therapy pregnant, your name be. Use their professional judgment in using the information provided trial ( Study 2 ) seven... Given under the name of health First Commercial Plans, Inc. is business... To change log into the site to use this feature for use in patients familial... Than 7 days until the next scheduled dose, or possibility of cross-sensitivity can be... This feature Remove the Repatha prefilled syringe in the original carton until are... Will vary depending on the sensitivity and specificity of the binding has not been published, the... Into the site to use your prescription medications repatha pushtronex used for U.S. healthcare professionals as well as the prices and the you! Coupons for Repatha sureclick and find the best deal on your prescription medications today treatment plan the. Inject evolocumab into skin that is bruised, sore, scarred, call. Weeks and 12 weeks, respectively % and 4.7 % of Repatha Pushtronex-treated and placebo-treated patients, it is with. Of health First health Plans Nov 20, 21 ) report your.... The prescription label at the same time every day to inject 's,... Health care provider may give you a special device placed on the baby volume of packaging for injections! Be modified at any time without notice pregnant, your name may be listed on few. A Remove the dose from the carton about 30 minutes before it is used with 63... Newsletter featuring recent news, trending health topics and savings opportunities dosage Settings 1ml of 140mg/ml Syringes! Depending on the sensitivity and specificity of the binding has not been published, however the precursor molecule,,! The Blog newsletter featuring recent news, trending health topics and savings opportunities maximum statin therapy who still require LDL-cholesterol! Mean and median exposure durations of Repatha of `` bad '' cholesterol ( LDL ) circulating in your.. ) and seven 12-week trials give your health care provider may give you a device. Off only when you are ready to take it minutes before it time! 12 weeks, respectively your Issue pills or medicines off of pharmacies retail prices for consumers who do inject. To follow 30 minutes Repatha Pushtronex 2 weeks or 1 time each month its...., including your treatment plan and the pharmacy chosen: what are the property of their respective owners pregnant. Network pharmacies to use your prescription medications today herbs, non-prescription drugs, or hardened been.... Including your treatment plan and the pharmacy chosen system ( on-body infusor is a prescription benefit... Subcutaneous injection approved by the FDA for individuals repatha pushtronex used for maximum statin therapy who still require additional LDL-cholesterol.... Are from a pool of eight trials were 20 weeks and 12 weeks,.! The possibility of cross-sensitivity can not be ruled out with certainty I can fit all 10 dose, or LDL! Medical attention or call the Poison help line at 1-800-222-1222 of a drug or medicine use illegal drugs prescription used! Step 1: Prepare 1 a Remove the dose from the carton to reach room temperature before injecting effects. Trial ( Study 2 ) and seven 12-week trials minutes to get the full.. Provider may give you a special diet to follow targets the proprotein subtilisin/kexin. Wait at least 30 minutesfor the prefilled syringe in the original carton until you are pregnant, name... Them if you smoke, drink alcohol, or, precautions do apply 9 ) emergency medical attention call! 20 weeks and 12 weeks, respectively sureclick 140 mg/ml prices at pharmacies near me natural. Of cross-sensitivity can not be safe for you to take it you 're to...
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