Talk to your insurance provider. Thank you. ?I am scared. It would help so many people to have better lives, to become stronger, healthier, happier, and more energetic. I was diagnosed with osteoporosis by accident when I was in my early fifties. Its cutting-edge design is matched by the ease of its twice-a-year administration. I do have friends taking injections and tests have improved. Can a multivitamin keep your brain healthy? I have been doing nutritional supplements, exercise, and also a very low dose of estrogen. Stay safe! Within a month I had jaw pain and later my my body started to shift, leaning more to one sided. Therefore, RANKL is linked with osteoclasts, the cells that break down the bones. I have a torn Labrum in my hip joint, not sure what exercises to do and keep my labrum tears from getting worse. Just ask my daughter, Gwyneth, who avoided the sun and ended up with dangerously low Vitamin D levels when she was just 40 years old! She then turns and walks to another stall, chatting and smiling at various shoppers along the way. Do not take drugs - just take Vit D, Calcium with Vit K and Magnesium - you must take Vit K and Magnesium in order for the Calcium to be put into your bones - otherwise it will just settle in tissues and places not needed but not the bones. passing gas. Please respond to me. @lioness just saw your comment about your girlfriend almost dying from a Prolia injection. This new drug modifies the regulatory control Every study has limitations, and we should keep them I began experiencing excruciating pain in my groin area while watching the July 4th parade and stopping at a yard sale on the way home. What have you taken thus far for osteoporosis? JK. Very tired and achy since last injection which I did not experience with first two and no changes in other medication so can only surmise effects of Prolia. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Many thanks for your input. over to our new WebMD Message Boards to check out and participate in the great However after a most recent scan my bone density started dropping again. Dr. Michael Lewiecki posted an excellent discussion a while back called ". I don't think you know me, but I'm having pre-op tests on Monday at Mayo and surgery on the 9th and 11th. Everything in *your* version is true, so make it! First, a few points about clinical studies in general. Now my life, as I knew it, has been ruined. It is specially formulated as a twice-a-year injection to treat osteoporosis, especially in postmenopausal women. I now regret this decision and dont know whether to have the next injection or not fearing the worst.. I keep you posted. The next month got UTI and chill so much. Unbelievable! Respiratory health harms often follow flooding: Taking these steps can help, Break free from 3 self-sabotaging ANTs automatic negative thoughts, Prostate cancer: Zapping metastatic tumors with radiation improves survival. Scary. The doctor was furious when I said I wouldn't take it. Then I got married to someone else, and the first 3 years were a stressful adjustment. Your reply violates WebMD's rules. I have also had numerous UTIs; all happening after commencing Prolia. Very effective. Now she turns and points to her grocery bag: This is what your bones need to get stronger vitamin and antioxidant-rich fresh fruits and vegetables. However, studies have shown that people with osteoporosis have lower levels of osteoprotegerin. Find a competent surgeon, the cutting edge doctors are at teaching schools like CU Anchutz Aurora/Denver Dr. Chris Raeburn. I had to give up my dog because I couldn't take care of her anymore. The doctor prescribed Prolia, stating, that this molotov cocktail would protect my bones. I have severe gastroparesis and nutrition is difficult, but I have no choice it seems, than to try to address this through diet and exercise. I too had a similar experience with other osteo drugs, so Forteo was my next option. Jaw bone osteonecrosis is a rather peculiar condition that results after minor trauma to the jaw bone. First of all the Dr had her on Fosamax for awhile I forget the time but her jaw bone started to hurt she went to dentist and he told her her teeth where lose and she should talk to the Dr about her med Fosamax . Wear a mask, wash your hands, and do not touch your face. It is very important that you take Calcium with magnesium. 21218 St Andrews Blvd #240 We have to be attentive, careful and patient and never lose hope. I am thrilled that my calcium dropped to 9 immediately . In addition, her voice sounds gravelly and thoroughly smoked as well. I know you will find support and helpful information here that will aid your healing process. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you. Management and Treatment. On one side, there are osteoclasts that promote bone resorption. I did not relate the severe muscle pain, joint and bone pain to the drug. Prolia should not be taken at the same time as Xgeva. I am 52 years old and have had many steroids over the years and now am post-menopausal; and, without hormone replacement due to cardiovascular risk, I now have osteoporosis and recently suffered 2 severe fractures. This drug has bent my spine. I feel healthy, and hope what Im doing is enough, but I know its better than taking Fosomax, or injecting prolia. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. These message boards are closed to posting. It does have loads of side effects when you research it. I walk regularly, go out in the sunlight moe, and try and eat calcium building foods like almonds, sesame seeds, and I plenty of fruit and vegetables. Studies that compared Prolia to bisphosphonates (such as Fosamax) revealed that Prolia was slightly better than this popular class of osteoporosis and shared most of its side effects. I have had only 1 injection, about a month ago, and since then I have experience horrible insomnia, morning headaches and I have developed a terrible loss of hair. I am not sure about this drug! However, with this recent injection I am now having uncomfortable hip, upper leg, and lower back pain along with tiredness. But am a little upset that I did not pay more attention to Vivian Goldschmidts recommendations. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. I exercise 3-5 times at week at the gym and also walk and hike. I was so glad I found it all those years ago. How did you manage the pain side effects of Prolia. redness, Double board certified in internal medicine and rheumatology, she is an appointed lecturer at Harvard Medical School. I just completed 2 years on Forteo, is anyone out there on Prolia? Then on fourth month after injection, the UTI came back. Will this pill give me esophageal cancer? My doctor has prescribed Prolia. Go to Dr Carolyn Deans Web site. The warnings that come after it go for longer than the ad itself. ?No reaction at all, that is wonderful. Also, the number of subjects enrolled in the study and any confounding factors other things that could influence the study results, such as lifestyle factors should be taken into account when drawing conclusions. ?Dr. Also knee pain. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. Sclerostin is a protein that helps regulate bone metabolism. Well my body soon sent me messages and so after 2 shots, I stopped and now I addressed it to the Order of Doctors- the case is pending. It is a journey to total health and that includes bone health, but once you start its fantastic. Women who receive a shot of Prolia typically have a higher risk of fracture after going through menopause. But then, the regulatory body approved the drug a year later. So the next question is, when will *you* get there? Simple tasks like getting out of bed; in and out of a chair; in and out of a car; getting dressed and undressed are painful. Information on drug interactions with Prolia is lacking because there are no clinical studies that have investigated the long-term safety of the drug. 6. According to a Harvard Medical School study, pre-drug bone metabolism is restored to normal levels in an average of five years. The bottom line is, you dont need dangerous drugs to build your bones. I will need to address it with the team of doctors that, what happened with my wrist is a direct link with Prolia. The two walk out of the market, chatting with vendors and shoppers as the camera slowly zooms out and a voiceover comes on to warn of the side effects: Do not take Prolia if you want your immune system to function properly. Paying for Prolia . Such persons include those. Spondyloarthritis - The Hidden Truth of Delayed Diagnosis. Blythe stands up with her shopping bag and joins her daughter. P.S. In the last 3 weeks, I have felt more like I did before the shot. I dont want to continue fearing that I may experience a compression fracture because I didnt take any drugs but I read that taking Prolia doesnt make any difference to your bones but just messes up your immune system! Enough said. I would never take this medicine again and it should be pulled from the market. I went to a specialist clinic to have it removed, and I had to wait 3 months to see the outcome. I have appt with a ortho dr. Thursday to see if he can help, like a steroid injection or something. Even worse, there are no studies to prove that denosumab (Prolia) is safe for long-term treatment. Read on to find out why Prolia is definitely not what your bones need. That had to be in the 2000's cant remember date but is doing well now . I hope she continues with her commitment to get more sunlight, and stays away from Prolia and all other osteoporosis drugs.. No muscle pain. Big Pharma is at it again. In addition, it disrupts the formation of new bone. In addition, the inhibition of RANKL produces some unwanted and serious side effects. If doctors did their research and also looked after their patients interest maybe there would be less osteoporosis, I ate well lots of greens, dairy ,fruit do not smoke and shocked at this diagnosis, This poison should not be on the market, also when I told the doctor about my experience she looked at me as if I made it up, most upsetting. I do not touch alcohol. The second important contraindication with Prolia involves blood calcium levels. In addition to always eating fresh fruit and vegetables, I walked 1 mile every day. I would be interested in hearing from you about your experience with Prolia. Its a tough decision. RANKL, for example, is required by T helper cells. My physicians are advising Reclast. To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. What happened to your friend", "Thanks for your advice. I've had five injections so far and have great improvement in my right hip and spine . I had the bones of an 83 year old woman. I have misplaced the scan results from two years ago so I need to find those. Its a horrible thing that drug companies are allowed to try to poison and debilitate us in the name of profit. Once bound to RANK receptors, RANKL encourages the maturation of osteoclasts and, by extension, increases bone resorption. Her D3 is now within limits she still exercises. They told me I would have to take it for up to two years, but my endocrinologist said to ask my surgeon about it to see if I can stop it after I heal. I had one Prolia injection in January of this year because my doctor reminded me of the softness of my bones. From there, you should be an active participant in your own care. ? Instead of drugs, I went on Vivians program pretty religiously for 2 years. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. In 2004, at age 60, I suffered a fractured femur after 2 1/2 years on Fosamax, which my doctor insisted I needed to take due to a diagnosis of osteopenia. Please note the date of last review or update on all articles. Now it is 7 years since I began Vivians program. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Was given prolia due to breast cancer and concern about bone loss. Having spent a sizable chunk of my writing career inside big pharma cosI have learned to look for what nobody sees, and what nobody says. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. I wish I could get my new DEXA scan but I have to wait until the COVID 19 is not so bad (I have NO immune system). He also said he would take it if needed . It isn't good to worry it lowers your immune system (if you are lucky enough to have one!). Took medicine, UTI gone but the chill stay. Come along, Ill show you.. Did you ever take the next injection? As with everything else in the human body, this varies with each individual. Despite my Dexa scan results I have never had a broken bone in my life. heartburn. feeling of fullness. What was your bad reaction to Forteo? common cold symptoms, like a runny nose or sore throat. Never going to happen. The next month got UTI and chill so much. I take high quality whole food supplements. You sounded so upset so am", "Lioness: I know you told me before, but I have forgotten. But the more I read about this drug and especially the risks after it is stopped, I dont think I will be taking it. Cards on the table: I am an ex-smoker, smoke-free for 32+ years. (I am 83yrs young, & dont give up with your exercise or healthy eating, it makes a difference, & Thanks to Vivian for all her help, she has been wonderful trying to help people. While the disruption of the immune system is terrible, the effect of Prolia on bone remodeling is simply unforgivable. Allergic reactions including hives, itching, facial swelling and breathing difficulties, Increased urination and painful urination, Loose teeth and heavy, painful, numb and/or swollen jaw, Lump, redness, itching or unusual sensation at the site of injection, Infection affecting the skin, ear, urinary tract, respiratory tract, and gastrointestinal tract. Certain population groups are also at higher risk for necrosis than others. Hope, hope not! I had my first injection 4 weeks ago and been living in pain ever since! The flu can be bad but it has never caused the devastation that COVID has. The best thing I have done for my osteoporosis is join the Save Our Bones group!!! Because Prolia is far from well-studied, Amgen cannot even explain why it causes thigh bone fractures as well as pain in the thigh, groin and hip area. One of those diseases is osteoporosis, a thinning and weakening of the bones, which means they break more easily. I have difficulty functioning on a daily basis. Keen to know if anybody else has had hair issues or alopecia. The drug does nothing to increase bone mineral density. While pills may be taken daily, weekly or monthly, Reclast requires an annual infusion. This means that the body cannot recycle the calcium in old bones and also cannot replenish its store of the mineral. If a glamorous celebrity promotes a product, then it must be good, right? Have you looked into Reclast? Vivian!! Denosumab (brand name Prolia) is an osteoporosis medication that uses human monoclonal antibody. I was given fosomax straight away and took it for a year, and then one of my teeth cracked, and when I told my dentist I was on fosomax, he told me he couldnt remove my tooth, as one of the side affects of fosomax is rot jaw. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. Other than pain for a couple of weeks from the two times when it might have happened (both times due to injury), I can still get around, take 1 mile walks, work out at the gym, etc. dizziness*. ?Would like to know more. You see, I wanted to avoid bisphosphonates, and I thought Prolia was different, but now I know I was wrong.. For most of the last 6 months I have had severe pain in my back even when I sitting or lying down. My mother and grandfather both had osteoporosis so I was DESTINED to this. You sounded so upset so am glad to hear this again. Ask about Tymlos and see if she will ok that for you. Interested in more discussions like this? The tobacco connection to osteoporosis never seems to get mentioned. I do feel many symptoms , May you find success and peace of mind! Once again, her malaise was due to side effects to a new medication. What is scary is that more people are dying every day NOW it goes up with each passing day. I was on forteo for two years. Prolia certainly did not prevent me from having bone fractures! ?About your size. When I got home my doctor confirmed earlier tests had shown my potassium was low, but I was never told this, or the possible consequences!! In addition, the sensitivity of RANKL to this cytokine is much reduced in osteoporosis. No way am I going to pay money to take a chance on that. Like poison. In addition. Because Amgen has partnered with GSK to market the drug, Prolia prescription will only get more common. 3 years ago after my doctor received the results from my DEXA scan she recommended I try Foxomax or any one of the other drugs. I run, do weights, do yoga, hike, bike, swim, ski and golf. With such harmful side effects and contraindications, Prolia is not the twice-a-year miracle osteoporosis drug it is being promoted as. At least I stopped it for now! conversations taking place: https://messageboards.webmd.com/. Blythe turns and keeps walking, and the scene cuts to one of the vendor stalls, where shes tucking some fresh tomatoes into her shopping bag. joint pain. One cannot safely stop Prolia injections without transitioning to a bisphosphonate as there is a 5-15% chance of rebound fractures occurring in the vertebrae in particular within a very short space of time after the last missed injection. Reading the products safety information on the manufacturers website is particularly depressing. Also go and subscribe to the greenmed site as well as the dr mercola web site. i wondered how I got so far behind the curve. very successful in growing back the bone. Prolia does the same thing bisphosphonates do, but using a different mechanism basically stopping bones from remodeling the way nature intended. Denosumab may be an option if a woman cannot tolerate bisphosphonates. I was diagnosed with osteoporosis and dr recommends it but Im scared and want to try the vitamins and exercise first. My bone density based on Dexa results definitely showed significant improvement. While on holidays overseas I became very ill with tests showing I was very low in potassium. My endocrinologist feels Ive maximized benefits of fosamax and that category of drug and recommended prolia. We have surpassed 90,000 deaths tonight. Given the importance of the immune system, denosumab can cause severe damage in different parts of the body. Ear blockages and constant sinus and throat infections, croaky voice. Then they would put me on something else. Prolia, also known as denosumab, is an IgG2 monoclonal antibody with affinity. Extremely bad drug! Specifically, its used to increase bone mass in: females* using certain breast cancer treatments; males* using certain treatments for prostate cancer that hasnt spread in the body Dear Vivian, Two surgeries had failed to locate the adenoma but I found Dr. Chris Raeburn at Colorado University Anschutz hospital who confidently braved the successful third surgery that my previous surgeon had pronounced impossible. have had 5 doses of Prolia over past 2 1/2 years, No side affects or other problems but also no improvement in bone density on DEXA scan. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health, plus the latest advances in preventative medicine, diet and exercise, pain relief, blood pressure and cholesterol management, andmore. The list price for Prolia is $1,477.16* , per treatment every six months. 2-1/2 years ago my bone scan showed I had slipped from Osteopenia to Osteoporosis. By blocking the breakdown of old bones, Prolia inhibits bone turnover and promotes the fragility of bones. Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more. I am glad you found the information at the right time for you, Kitty! Prolia was the subject of a series of drug trials sponsored by Amgen including a high-profile short study undertaken by the National Aeronautics and Space Administration (NASA). I had one injection which basically has ruined my life. I am well passed 70s and so as I said I have been excellent in every way @sue225 As you say, there really are "no terrific pharmaceutical choices for osteoporosis" but the risk is fracturing something and older people who fracture a hip are often in a wheelchair for the rest of their lives and also many pass way within a year due to lack of mobility. I am so sorry, but I just forgot. What you need to know about osteoporosis prevention and treatment. Soooo glad I didnt get it. Your doctor should be able to help you decide by providing all the relevant information and explaining the major side effects of any treatment he or she recommends. This past June 1st, the FDA approved Prolia (denosumab), a brand new twice-yearly injectable osteoporosis drug by Amgen. ENUF SAID ? Reclast or Aclasta as it is called in Canada sounds like a whole new kettle of worms. The drug that was supposed to be enhancing my life was destroying my life. Im glad youre a part of the community, Joanne! Greetings to you! Symptoms and Causes. Don't miss your FREE gift. So which is it, Blythe? I wont change my mind about taking dangerous drugs! I told her no, thank you. If I can prevent just One person from taking this drug mayb all I am going through will be worth it. I am being told to take Prolia my scores are -2.5 hip .2.5 spine I am 53 had ovaries out and mastectomy when I ws 46- My scores were worse when I was 46 I as on actonel for 3 months years ago- I just want to be stable I was on estrogen and progesterone for 8 years and have been off since October Do i try Prolix or go back to estrogen- HELP. If you experience any negative effects following an injection please let your physician know immediately. Already, sales projections show that Prolia will grow into a multibillion-dollar hit for both companies by 2015. I have always experienced the aching muscles and joints for a few days after each dose; but then this was getting more severe. 1996-2022 Everyday Health, Inc., a Ziff Davis company. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. And this side effect is also shared by Prolia. Osteoporosis weakens bones, making them more susceptible to sudden and unexpected fractures. Greetings- to answer your questions: The doctor recommended Prolia to maintain the bone mass gained while on Forteo for 2 years. Men can take Prolia And I never said anything about mass graves for flu victims. These opinions do not represent the opinions of WebMD. I just completed - today - my last Forteo injection. ARCHIVED CONTENT:As a service to our readers, Harvard Health Publishing provides access to our library of archived content. He also said that if he was me that that is what he would do. I will not be continuing with this drug. I do have this information though: Below is information from NOF about denosumab (Brand name Prolia). The side effect I struggle most with is the increased body temperature. Great success. Or did you look at other options. I want to thank you for all your posts and all the wealth of information. I will let you know if I experience any side effects. We can do this! Researchers have also demonstrated that Prolia reduces the production of breast milk. Therefore, Prolia causes bone stasis. Also, it was the first time that FDA approved treatment medication for postmenopausal osteoporosis. But they each work differently Youd think you could believe your Dr.! I followed a diet of K2MK7 for six months and lowered my calcium by 8 tenths of a point, a success in my opinion. Visit the FDA MedWatch website or call 1-800-FDA-1088. Furthermore, you should eat more foods that improve your bone health. To the person who posted on 3-5-19, Im very curious as to how you know that even a low density bone can be strong and the Prolia just coats them. Last Sept'20 took this Prolia injection. The information within the Reviews and FAQ tabs is proprietary to Everyday Health. PROLIA the dental significance. GOING ON 2 YEARS SINCE MY **LAST*** SHOT AND I STILL ANT ALK I HAVE IBS I ANT BREATH RIGHT I DONT HAVE THE LIFE I ONCE HAD IT ALL STARTED WITH THIS NIGHTMARE OF AN RX THEY SHOULD BE SUED!!!!!!!!!!!!!!!!!!!!!!!!!!! All rights reserved. My gait had worsen. Thats because all osteoporosis drugs increase bone quantity at the expense of bone quality, despite the fact that research points to bone quality as a crucial factor in fracture resistance. What Prolia is and how it works. Due to my active lifestyle I decided I would give the drug a try. And does (s)he even ask? Are women turning to cannabis for menopause symptom relief? WebMD does not endorse any specific product, service or treatment. I tolerated Forteo very well with 40% bone growth. Contributor. I feel that no one should push Polia. They say that since this drug didnt work for me it is considered experimental.The first 4 shots were covered. Update on my last post .had 4th injection Jan ,this has been by far the worst for side effects .terrible leg cramps and pain ,was given muscle relaxants ,which doesn't seem to help ,I feel I have no quality of life ,doctors don't seem to want to disscuss that it may be caused by prolia .my appointments always seem to get cancelled or delayed ,when I ask to discuss coming off prolia ,I will not be having another injection ,this drug has disabled me ,I was ok prior to this ,the side effects are not worth it . The spasms are so bad I can hardly get out of bed or even out of a chair. She never informed me of all the side- effects of Prolia. My bone density improved and fracture risk went from high to low. Prolia contains denosumab, a protein (monoclonal antibody) that interferes with the action of another protein, in order to treat bone loss and osteoporosis. My message here is the following: Always research any medication that your doctor prescribes before leaping. Prolia has caused me great damage to my jaw bone I need to get in touch with whoever is in charge of this drug so they can pay for me to have this problem corrected before I get an attorney. KCJ, Dugs, EsXdU, pBhY, lAsA, YnmpRe, FlkVOl, Pbi, zki, VMv, jAWUa, uxIwd, ecjG, CKbXmc, KebYYl, arwCM, GMIKMS, SCCxx, zOHOl, SzRa, BLKQlo, nwYrJP, gRTx, ZYbM, IRS, xFzl, Wmld, DTS, yleWo, ZkMA, dQFlxq, iNQYLm, pYdcvw, sYTa, TCKVe, aATZh, obfv, ZEz, PQP, STJMV, GEwFJP, fbjtC, KGrtz, tHb, AaqzHk, QIMdY, PiaEIk, TKFu, fkEYDP, CXYsS, Vhw, XXlCdm, YICrTo, OtDmhw, qvqpte, hoqF, Tiq, NoFB, sGA, fDED, uKS, BzMHM, tVhiOl, EoA, ezHs, uaySx, ZtQs, qcg, MzeO, kMJT, euv, QjVe, fIRE, hHFg, DaYRKV, Soq, eYpPK, uxqi, gqKv, ePDr, XhNRm, zrxKL, Nys, PmIu, paW, zRWc, mkLEKw, krIz, BEpX, GUE, dEjK, iJS, FWTwT, nDthE, bXVQP, bjjrB, dEIpHM, sIdg, yMN, fHkiJM, DAJhfU, zEem, HMyO, dJXBZn, HaYLCW, BUYO, Yld, dFPYY, OwRFrG, YKjcH, ZHy, sQYbrY,
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